Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline.
Identifieur interne : 002737 ( Main/Exploration ); précédent : 002736; suivant : 002738Inverse relationship between brain noradrenaline level and dopamine loss in Parkinson disease: a possible neuroprotective role for noradrenaline.
Auteurs : Junchao Tong [Canada] ; Oleh Hornykiewicz ; Stephen J. KishSource :
- Archives of neurology [ 0003-9942 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Autopsy, Brain Chemistry (physiology), Case-Control Studies, Dopamine (metabolism), Female, Humans, Levodopa (therapeutic use), Locus Coeruleus (pathology), Male, Norepinephrine (metabolism), Nucleus Accumbens (metabolism), Parkinson Disease (metabolism), Substantia Nigra (pathology).
- MESH :
- chemical , metabolism : Dopamine, Norepinephrine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- metabolism : Nucleus Accumbens, Parkinson Disease.
- pathology : Locus Coeruleus, Substantia Nigra.
- physiology : Brain Chemistry.
- Aged, Autopsy, Case-Control Studies, Female, Humans, Male.
Abstract
Experimental findings using animal models of Parkinson disease (PD) suggest that noradrenaline might protect dopamine neurons from damage.
DOI: 10.1001/archneur.63.12.1724
PubMed: 17172611
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Experimental findings using animal models of Parkinson disease (PD) suggest that noradrenaline might protect dopamine neurons from damage.</div>
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